ʻO ka granulomatosis o Wegener he maʻi maʻi e pili ana i nā maʻi nui o ka holomua. ʻO nā vasculitis vasicitis a me ka granulomatosis o Wegener he pathologies pili i ka pili, no ka mea ua hanaʻia nā'epikopi (antineutrophil cytoplasmic) i loko o granulomatosis,ʻo ia hoʻi keʻano o ka vascitisitis e pili ana i ka ANCA.
Nā kumu o ka granulomatosis o Wegener
ʻO ka granulomatosis o Wegener e pili ana i ka autoimmune, no laila, e hiki ke loaʻa kahi huaʻano. ʻO kaʻoiaʻiʻo,ʻo ka granulomatosis kahi kūponoʻole o ka pane. No laila,ʻo nā hōʻailona o ke ahulau he mau kīnā - HLA 添加 B 张 _7, B_8, 着 う り _2, 添加〗 _w7.
ʻO ka hana o nā pathogens e hoʻokaniʻia hoʻi e nā antipododic antiteutrophil e like me ka proteinase-3.
ʻO ka granulomatosis o Wegener - hōʻailona
ʻO nā hōʻailona o granulomatosis ka hapanui o ka manawa o 40 mau makahiki, akā,ʻaʻohe mea kūpono o ka manaʻo male.
ʻO Granulomatosis - kaʻona o nā paia o nā moku liʻiliʻi a me nā moku: venules, capillaries, arteries and arterioles. Ma ke kaʻina hana, ka papahana'ōmaha kiʻekiʻe, nā puʻupaʻa, nā maka, nā mumū, a me nā mea'ē aʻe.
Eia nāʻano hōʻailona:
- ka nui - ka poho kaumaha, ka nāwaliwali, ka mealgia, ke ākeaʻana, ke kuni, nā mea maʻamau, nā maʻi'ākau;
- 'ōpiopio - ka polyneuropathy asymmetric;
- kaʻike - kaʻike o ka nerve maʻamau, ka makapō, episcleritis me ka granuloma a me ka exophthalmos;
- kaʻili - ka'āpala me nā'enekeneke kino;
- nā kupa - glomerulonephritis , hiki ke lawe i kahi wikiwiki;
- Māmā - nā maʻi e ulu i loko o 75% o nā maʻi i keʻano o infiltrates, e hana i nā hale i ka wā o ka palaho; hiki keʻikeʻia kēia me keʻano nui, ka moe.
- ia nā'ōmaʻomaʻa hauʻoli - e pili ana i ka 90% o nā maʻi i keʻano o ka rhinitis me ka hoʻoholo hilo-haemorrhagic a me ka ulceration; ʻO ke poʻomanaʻo o ka septum nasal e alakaʻi aku ai i ka hōʻino lio; Eia kekahi, pili ka liona i ka larynx, pepeiao, keʻakeʻa, paranasal sinus, kahi i mālamaʻia ai kahi hana hana.
Heʻeluaʻano o mākou i kahi granulomatosis o Wegener:
- ia i ka loli - 'o ia ka hopena o ka' aoʻao o ka'ōmahe hanu kiʻekiʻe;
- Kūpikipiki - me nāʻano o nāʻano he nui, a ua hele pū kēia me ka maʻi wela, ka maʻi kekoko pū, ka hō'ī a me ka hāʻule o ka naʻau.
ʻIke i ka granulomatosis o Wegener
ʻO kēia diagnostics ua hanaʻia e kahi kahakai pale e pili ana i nāʻikepili:
- nā hoʻokolohuaʻana i ke koko - mea lāʻau a me ke koʻikoʻi, hikiʻole ke hōʻoia granulomatosis, akā kōkua i ka hoʻoponoponoʻana i nā maʻi'ē aʻe;
- ka hoʻopuka urine - hiki iā ia ke hōʻoia a wehe paha i nā hōʻino hōki (ua hoʻoholoʻia keʻano o ka maʻi);
- Nānā X-ray o ka hanaʻonika a me ka helu (ka hoʻokomo helu i hoʻohālikelikeʻia i nāʻike iʻikeʻia ma mua o ka mea i loaʻa iā X-ray);
- nā lāʻauʻoki lāʻau -ʻo kahi wale nō i hoʻomaopopo a hōʻole i ke alo o granulomatosis; lawe nā kauka i kaʻiʻo mai ka ihu a i ka puʻu, a ma kekahi mau mea, nā puʻupaʻa a me nā mumū.
Hanaʻia o kahi maʻi nui o Wegener
Hoʻomaʻaʻia keʻano o ia maʻi, ma keʻano, me ka komoʻana o nā corticosteroids a me nā cytostatics, e ho'ēmi ana i ka hana
Me nā hōʻino hana'ekepiliʻino, ma kekahi mauʻano, pono ka mea maʻi e hoʻoneʻe i ke kino.
ʻO ka granulomatosis o Wegener - prognosis
Ināʻaʻole i hoʻomakaʻia ka lāʻau lapaʻau i ka manawa kūpono, a laila, e hiki mai ka hōʻailona maikaʻiʻole i loko o nā mahina 6-12, aʻo ka lōʻihi o ke olaʻanaʻaʻoleʻoi aku i ka 5 mau mahina.
I keʻano o ka lāʻau lapaʻau, e pili ana i ka 4 mau makahiki, ma kekahi mau manawa he 10 mau makahiki. Hiki hiki ke ho'ōlaʻia kahi ola piha i ka manawa o ka uluʻana o ka lāʻau lapaʻau.